Sepsis y biomarcadores
Resumen
La sepsis es una de las principales causas de muerte en pacientes gravemente enfermos a pesar del uso de antimicrobianos modernos y terapias de reanimación. La sepsis y el choque séptico son importantes problemas de salud, afectando a millones de personas en todo el mundo cada año y matando a uno de cada cuatro(1).
La respuesta séptica es una cadena extremadamente compleja de eventos que involucran procesos inflamatorios y antiinflamatorios, reacciones humorales y celulares asociadas a anomalías circulatorias. El diagnóstico precoz es un tema importante, ya que la instauración temprana de una terapia apropiada, incluyendo los antibióticos, se asocia con mejores resultados y marcada disminución de la mortalidad(2).
Citas
1. Rhodes A, Evans L, Alhazzani W, Levy M, Antonelli M, Ferrer R et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304-377.
2. Minasyan H. Sepsis and septic shock: Pathogenesis and treatment perspectives. J Crit Care. 2017;18(40):229-242.
3. Long B, Koyfman A. Ready for Prime Time? Biomarkers in Sepsis. Emerg Med Clin North Am. 2017;35(1):109-122.
4. Hofer N, Zacharias E, Muller W, Resch B. An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology. 2012; 102(1):25-36.
5. Javed A, Guirgis FW, Sterling SA, Puskarich MA, Bowman J, Jones AE. Clinical predictors of early death from sepsis. J Crit Care. 2017;23(42):30-34.
6. Wilhem J, Hettwer S, Schuermann M, Bagger S, Gerhardt F, Mundt S, et al. Elevated troponin in septic pacients in the emergency department: frequency, causes and prognostic implications. Clin Res Cardiol 2014;103(7):561-7.
7. Bessiere F, Knhenifer S, Dubourg J, Perez X. The prognostic significance of troponin elevation in patients with sepsis: a meta-analysis. Heart Lung 2015;44(1): 75-81.
8. Taylor R, Jones A, Kelly S, Simpson M, Mabev J. A review of the Value of Procalcitonin as a Marker of Infection. Cureus. 2017;9(4);e1148.
9. Rhee C. Using Procalcitonin to Guide Antibiotic Therapy. Open Forum Infect Dis. 2016;4(1):ofw249.
10. Sager R, Kutz A, Mueller V, Shuetz P. Procalcitonin-guided diagnosis and antibiotic stewardship revisited. BMC Med. 2017; 15(1):15.
11. Henriquez-Camacho C, Losa J. Biomarkers for Sepsis. Biomed Res Int. 2014; 2014:547818.
12. Skibsted S, Jones A, Puskarich M, Arnold R, Sherwin R, Trzeciak S, et al. Biomarkers of Endothelial cell activation in early Sepsis. Shock. 2013; 39(5):427-432.
13. Sandquis M. Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Rev Clin Inmunol. 2014; 10(10):1349-1356.
2. Minasyan H. Sepsis and septic shock: Pathogenesis and treatment perspectives. J Crit Care. 2017;18(40):229-242.
3. Long B, Koyfman A. Ready for Prime Time? Biomarkers in Sepsis. Emerg Med Clin North Am. 2017;35(1):109-122.
4. Hofer N, Zacharias E, Muller W, Resch B. An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology. 2012; 102(1):25-36.
5. Javed A, Guirgis FW, Sterling SA, Puskarich MA, Bowman J, Jones AE. Clinical predictors of early death from sepsis. J Crit Care. 2017;23(42):30-34.
6. Wilhem J, Hettwer S, Schuermann M, Bagger S, Gerhardt F, Mundt S, et al. Elevated troponin in septic pacients in the emergency department: frequency, causes and prognostic implications. Clin Res Cardiol 2014;103(7):561-7.
7. Bessiere F, Knhenifer S, Dubourg J, Perez X. The prognostic significance of troponin elevation in patients with sepsis: a meta-analysis. Heart Lung 2015;44(1): 75-81.
8. Taylor R, Jones A, Kelly S, Simpson M, Mabev J. A review of the Value of Procalcitonin as a Marker of Infection. Cureus. 2017;9(4);e1148.
9. Rhee C. Using Procalcitonin to Guide Antibiotic Therapy. Open Forum Infect Dis. 2016;4(1):ofw249.
10. Sager R, Kutz A, Mueller V, Shuetz P. Procalcitonin-guided diagnosis and antibiotic stewardship revisited. BMC Med. 2017; 15(1):15.
11. Henriquez-Camacho C, Losa J. Biomarkers for Sepsis. Biomed Res Int. 2014; 2014:547818.
12. Skibsted S, Jones A, Puskarich M, Arnold R, Sherwin R, Trzeciak S, et al. Biomarkers of Endothelial cell activation in early Sepsis. Shock. 2013; 39(5):427-432.
13. Sandquis M. Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Rev Clin Inmunol. 2014; 10(10):1349-1356.
